| Two years before admission | Diagnosed with autoimmune hyperthyroidism. Received treatment with stand-alone thionamide (carbimazole) for two months before it was discontinued due to neutropenia. |
| Four weeks before admission | Signs and symptoms of hyperthyroidism (free thyroxine (T4): 79 pmol/L, free triiodothyronine T3: 47 pmol/L), prescription of thionamide and a non-selective beta-blocker. |
| Two days before admission | Thionamide was discontinued again due to neutropenia. |
| Day 0 | Admitted to her local hospital with fever, tachycardia, neutropenia, tonsillitis, suspected sepsis and a diagnosis of thyroid storm. |
| Day 1-3 | Treatment with beta-blocker, antibiotics, glucocorticoids and (commencing on day 3) iodine solution. |
| Day 4 | Sudden circulatory collapse with pulseless electrical activity (PEA). Cardiopulmonary resuscitation (CPR) was started and return of spontaneous circulation (ROSC) was obtained after 4 minutes. Transferred to tertiary care university hospital. Echocardiography demonstrated severe biventricular cardiac failure (severely hypokinetic left ventricle with ejection fraction <20%). Inotropic support with dobutamine was ineffective. Recurrent cardiac arrests, with PEA. Established on V-A ECMO support. Iodine solution dosages were increased and levosimedan infusion was started. |
| Day 7 | Complete recovery of myocardial function. V-A ECMO circuit was discontinued and she was extubated the next day |
| Day 12 | Surgery with total thyroidectomy |
| Day 28 | Discharged without cognitive sequelae and with normalized cardiac function. Close follow-up by endocrinologist |