Day 1	A 72-year-old patient with a critical course of COVID-19 (severe acute respiratory syndrome coronavirus 2) infection admitted to the intensive care unit (ICU) for intubation, inotropes, and continuous veno-venous hemofiltration
Day 21	Extubation
Day 23	Re-intubation due to progressive respiratory insufficiency Computed tomography (CT) thorax angiography: severe COVID-19 related bilateral ground glass pattern of the lungs without signs of pulmonary embolism Computed tomography angiography: free-floating thrombus in the distal thoracic aorta Start unfractionated heparin therapy
Day 24	Physical examination: blue toe syndrome
Day 25	Computed tomography angiography vasculature lower extremities: occlusion of the right posterior tibial artery
Day 30	Dark blue toes/signs of toe necrosis
Day 30	Follow-up CT angiography: decrease of the aortic thrombus load
Day 35	Weaning from mechanical ventilation Stop heparin therapy, start oral anticoagulants
Day 45	Intensive care unit acquired weakness and ongoing delirium
Day 90	Normal cognitive functions, substantial physical rehabilitation in progress
Day 150	Surgical surveillance and amputation of necrotic toes, general daily life activities independently