Appendix 1 . Original version of 12-item Pruritus Severity Score (12-PSS) questionnaire.

Question		Possible answers	Scoring
(1)	How often did you feel pruritus within the last 3 days?	(i)All time (ii)All morning/afternoon/evening/night long itch episodes (iii)Occasionally, short itch episodes	3 points 2 points 1 points
(2)	Did pruritus hinder your ability to do simply things, like watching TV, hearing music, etc..?	(i)Yes (ii)No	1 points 0 points
(3)	Did you feel irritated or nervous because of your itching?	(i)Yes (ii)No	1 points 0 points
(4)	Did your pruritus cause you depressed?	(i)Yes (ii)No	1 points 0 points
(5)	Did your pruritus impede your work or learning abilities?	(i)Yes (ii)No	1 points 0 points
(6)	Did you scratch your skin because of itching?	(i)Yes (ii)No	1 points 0 points
(7)	Did scratching bring you relief?	(i)Yes (ii)No	1 points 0 points
(8)	Were you able to refrain from scratching?	(i)Yes (ii)No	1 points 0 points
(9)	Did you wake up during last night because of pruritus?	(i)No (ii)Yes, 1-2 times (iii)Yes, 3-4 times (iv)Yes, 5 and more times	0 points 1 points 2 points 3 points
(10)	Could you assess the severity of your pruritus within last 3 days?	(i)Very mild (ii)Mild (iii)Moderate (iv)Severe (v)Very Severe	1 points 2 points 3 points 4 points 5 points
(11)	Could you indicate pruritus location?	(i)Single locations of pruritus (ii)Large body areas (iii)Generalized pruritus	1 points 2 points 3 points
(12)	Are excoriations or other scratch lesion present?	(i)Yes (ii)No	1 points 0 points