Table 1.
Dysregulated circRNAs and their biological function in PTC.
| circRNA | circRNAID | chromosomelocation | Length | Host gene | Function | Tissues (T/N) | reference | |
|---|---|---|---|---|---|---|---|---|
| Upregulation | ||||||||
| circRASSF2 | hsa_circ_0059354 | chr20:4760668-4766974 | 4418nt | RASSF2 | cell proliferation and cell apoptosis | 112pairs | (13) | |
| circFNDC3B | hsa_circ_0006156 | chr3:171965322-171969331 | 526nt | FNDC3B | cell proliferation and cell apoptosis | 42pairs | (14) | |
| circFOXM1 | hsa_circ_0025033 | chr12: 2966846-2983691 | 3410 nt | FOXM1 | cell proliferation, clone-forming, apoptosis, migration and invasion | 78pairs /20 pairs |
(15, 16) | |
| hsa_circ_0058124 | hsa_circ_0058124 | chr2:216270960-216274462 | 864nt | FN1 | cell proliferation, tumorigenicity, tumor invasion, and metastasis | 92pairs | (17) | |
| hsa_circ_0039411 | hsa_circ_0039411 | chr16:55523562-55540586 | 4418nt | MMP2 | cell growth, migration, invasion and cell apoptosis | 46pairs | (18) | |
| circBACH2 | hsa_circ_0001627 | chr6: 90959407–90981660 | 2995nt | BACH2 | cell proliferation, migration and invasion | 40pairs | (19) | |
| circRAPGEF5 | hsa_circ_0001681 | chr7: 22330793–22357656 | 516nt | RAPGEF5 | cell proliferation, migration, and invasion | 30pairs | (20) | |
| Has_circ_0008274 | hsa_circ_0008274 | chr11: 96485180-96489456 | 244nt | UGGT2 | cell proliferation and invasion | 142pairs | (21) | |
| circEIF6 | hsa_circ_0060060 | chr20:33867368-33872594 | 799nt | EIF6 | autophagy, cell apoptosis | 6pairs | (22) | |
| circZFR |
hsa_circ_0072088 | chr5:32379220-32388780 | 693nt | ZFR | cell proliferation, migration and invasion | 41pairs |
(23) | |
| circRNA_102171 |
– | – | 309nt | SMURF2 | cell proliferation, migration and invasion, apoptosis | 47pairs |
(24) | |
| circNUP214 | hsa_circ_0089153 | chr9:134011326-134022971 | 1102nt | NUP214 | cell proliferation, invasion, migration and tumorigenesis | 30pairs |
(25) | |
| hsa_circ_0004458 | hsa_circ_0004458 | chr8: 18656804-18662408 | 448nt | PSD3 | cell proliferation, cycle, and apoptosis | 48pairs |
(26) | |
| circ-0103552 | hsa_circ_0103552 | chr15:43294752-43314999 | 920nt | UBR1 | cell invasion and migration | 56pairs | (27) | |
| circ_0067934 |
hsa_circ_0067934 | chr3:170013698-170015181 | 170nt | PRKCI | cell proliferation, migration, and invasion and apoptosis | 57pairs |
(28) | |
| circMAN1A2 | – | – | – | – | - | 57T/121N | (29) | |
| circNEK6 | hsa_circ_0088483 | chr9:127055127-127101944 | 911nt | NEK6 | cell growth and invasion | GSE3678 GSE93522 | (30) | |
| hsa_circRNA_007148 | – | – | – | – | – | (31) | ||
| Down-regulation | ||||||||
| circ-ITCH |
– | – | – | – | cell proliferation, invasion and apoptosis | 14pairs | (32) | |
| hsa_circ_0137287 | hsa_circ_0137287 | chr8:92301363-92307931 | 284nt | SLC26A7 | – | 120T/60N | (33) | |
| hsa_circRNA_100395 | – | – | – | – | – | (34) | ||
| hsa_circRNA_047771 | – | – | – | – | – | (35) | ||
T, Tumor tissue; N, Normal tissue.