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. 2021 Jan 21;11:503256. doi: 10.3389/fgene.2020.503256

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Copyright © 2021 Gao, Zhang, Chen, Li, Wang, Wen, Xie, Mai, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac fibroblast-specific DE-microRNA and DE-lncRNA. (A) RT-qPCR validation of microRNA predicted from the 13 DE-mRNA (shown in Figure 1). n = 3 per group. (B) DE-lncRNA derived from the overlap of GSE116250 and GSE97358 datasets. (C) RT-qPCR validation of selected two mRNA, three microRNA and two lncRNA in TGFβ 1-, AngII- and PDGF-BB-treated HCFs. (D) RT-qPCR validation of the two mRNA, three microRNA, and two lncRNA in PBS-treated HCF-aa and TGFβ1-treated HCF-aa. n = 3 per group. *P < 0.05, **P < 0.01, ***P < 0.001. #, results represent the microRNA cluster due to few nucleotides difference inside the cluster. miR-92a-3p, miR-92a-3p/92b-3p cluster; miR-30a-5p, miR-30a-5p/30d-5p cluster; miR-106-5p, miR-106a-5p/20a-5p/20b-5p/17-5p/93-5p cluster.