Table 2.
Key Clusters of chronic conditions.
| Cluster name | Conditions with strong associations* (>95%) | Conditions with moderate associations* (20–95%) | Sample frequency n(%) | US insured population frequency n(%)** |
|---|---|---|---|---|
| Metabolic syndrome | Hypertension High Cholesterol Diabetes |
Eye problems; other neurological disorder; other endocrine disorder; coronary artery disease; osteoarthritis; weight-loss; obesity; chronic obstructive pulmonary disease (COPD) | 110,946 (11.9%) | 14,257,585 (12.2%) |
| Age-related disease | Osteoarthritis Hypertension High Cholesterol |
Diabetes; other neurological disorder; eye problems; other endocrine disorder; peptic ulcer disease exclude bleed; coronary artery disease | 65,356 (7.0%) | 8,990,408 (7.7%) |
| Renal failure | Renal Failure | Hypertension; high cholesterol; eye problems; diabetes; other neurological disorders; weight loss; cardiac arrhythmias; coronary artery disease | 50,373 (5.4%) | 6,602,939 (5.6%) |
| Respiratory | Allergy COPD |
Hypertension; high cholesterol; peptic ulcer disease exclude bleed; depression; other neurological disorders | 44,486 (4.8%) | 5,234,597 (4.5%) |
| Cardiovascular disease | Hypertension CAD Cardiomyopathy High Cholesterol |
Diabetes; cardiac arrhythmias; eye problems; COPD; other neurological disorders; congestive heart failure; osteoarthritis | 34,807 (3.7%) | 4,982,731 (4.3%) |
| Cancer female | Malignant Neoplasm (females) | Hypertension; high cholesterol; other endocrine disorder; eye problems | 37,062 (4.0%) | 4,992,607 (4.3%) |
| Cancer male | Malignant Neoplasm (males) | Hypertension; high cholesterol; eye problems; diabetes | 32,291 (3.5%) | 4,788,380 (4.1%) |
| Physical/mental debilitation | Depression Chronic Pain |
Hypertension; alcohol abuse; other neurological disorder; anxiety; peptic ulcer disease exclude bleed; COPD; diabetes; high cholesterol; weight loss; liver disease; enterocolitis | 23,897 (2.6%) | 1,802,778 (1.5%) |
| Mental health disorders | Depression Anxiety Hypertension |
High cholesterol; other neurological disorder; alcohol abuse; peptic ulcer disease exclude bleed; COPD; diabetes; osteoarthritis | 12,652 (1.4%) | 1,147,493 (1.0%) |
| HIV/AIDS | HIV/AIDS | Hypertension; high cholesterol; alcohol abuse; depression; weight loss | 2,890 (0.31%) | 252,688 (0.2%) |
*
The second column reports the main chronic conditions that were present in over 95% of patients falling within that cluster; column three reports conditions that were present in 20–95% of patients within that cluster.
**
Weighted and extrapolated to the US insured population.