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. 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991

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Copyright © 2021 Zhang, Bai, Zhang, Zheng, Lu, Liang, Lin and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detrimental effects of SNRNP200 p.Arg2030Cys in zebrafish. (A) Morphological changes at 3 dpf after injections of SNRNP200^WT, SNRNP200 p.Arg2030Cys. There is a significant difference of systemic deformations among groups. (B) Statistics of normal, deformed, and dead zebrafish after injection with SNRNP200 p.Arg2030Cys, SNRNP200^WT from 2 to 4 dpf. Data are shown as mean + SD from technical triplicates. n: total number of larvae for each group from triple experiment. ***P < 0.001. (C) Immunostaining analysis of the zebrafish larvae injected with different mRNAs at 3 dpf for rhodopsin (green). The normal zebrafish revealed abundant expression of rhodopsin in the IS/OS layer (D–I) by contrast, the reactivity of rhodopsin was significantly diminished in SNRNP200^c.C6088T-injected larvae.