Table 2.
a,b. Primary outcome measures, neuropsychological tests and secondary outcome measures, psychosocial and health questionnaires.
| a. | ||
|---|---|---|
| Primary outcome measures | ||
| 17 Neuropsychological domain/individual tests and subtests | ||
| Attention/executive function | ||
| Digit span (WAIS-V) (80) | ||
| Forward | ||
| Backwards | ||
| Total: forward + backward | ||
| Delis-Kaplan executive function test (DKEF) trails (73) | ||
| Trails 2 | ||
| Trails 4 | ||
| Color-Word interference (Stroop) (73) | ||
| Trial 3 | ||
| Trial 4 | ||
| Verbal memory and learning | ||
| California verbal learning test II (CVLT-II) (72)* | ||
| Total trials 1–5 (learning) | ||
| Short delay free recall | ||
| Short delay cued recall | ||
| Long delay (20 Min) free recall | ||
| Long delay (20 Min) cued recall | ||
| Connor's continuous performance test II (CPT) (81, 82) | ||
| Mean RT for % correct detections | ||
| % False alarms | ||
| Detectability (d') | ||
| Visuospatial/memory | ||
| Rey osterrieth complex figure test (ROCFT) (83–85) | ||
| Immediate recall | ||
| Delayed recall | ||
| b. | ||
| Secondary outcome measures | ||
| 46 psychosocial and health questionnaires/self reports and subscores | ||
| PCL-C PTSD checklist civilian (78) | ||
| Visual analog pain rating scale (VAS) (86) | ||
| Short form McGill pain questionnaire (77) | ||
| West Haven-Yale Multidimensional Pain Inventory (WHYMPI) (87) | ||
| Part A | Part B | Part C |
| Interference Support Pain severity Life-control Affective disorders |
Negative responses Solicitous responses Distracting responses |
Household chores Outdoor work Activities away Social activities General activity |
| Multi-dimensional fatigue inventory (88) | ||
| General fatigue | ||
| Physical fatigue | ||
| Reduced activity | ||
| Reduced motivation | ||
| Mental fatigue | ||
| Beck Depression Inventory II (BDI-II) (89) | ||
| Health Symptom Checklist (HSC) (67) (raw score and frequency score for each domain) | ||
| General health | ||
| Musculoskeletal pain | ||
| Mood | ||
| Cognitive | ||
| Gastrointestinal | ||
| Fatigue/sleep | ||
| Veterans RAND 36 item health survey, SF-36V Plus (90, 91)** | ||
| Physical functioning Role limitations due to Phys. Fct. Bodily pain General health Vitality |
Social functioning Role limitations due to Emot. and mental Health problems Mental health †Physical composite score †Mental composite score |
|
| Pittsburgh Sleep Quality Index (PSQI) (92) | ||
| Global PSQI score | ||
| Epsworth sleepiness scale (93) | ||
| Karolinska sleepiness scale (94) | ||
*
Alternate Version administered at every other testing session to avoid practice effects.
**
Developed by RAND as part of the Medical Outcome Survey Study.
†
Represents a combination of the other HSC subtests within the domains of mental health or physical health.