Table 1.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that are significantly enriched with genes associated with progression-free survival (PFS) in locally advanced prostate cancer (LAPC).
| KEGG ID | Pathway name | Enrichment p-value | Enrichment FDR | Genes |
|---|---|---|---|---|
| Enriched with upregulated genes | ||||
| hsa05202 | Transcriptional misregulation in cancer | 1,53E-05 | 1,98E-03 | CEBPB, RARA, GADD45B, CDKN1A, NR4A3, IGF1, SUPT3H |
| hsa04668 | TNF signaling pathway | 1,12E-04 | 7,29E-03 | BCL3, CEBPB, JUNB, SOCS3, IRF1 |
| hsa04975 | Fat digestion and absorption | 8,31E-04 | 3,60E-02 | PLA2G5, CD36, PLA2G2A |
| Enriched with downregulated genes | ||||
| hsa05160 | Hepatitis C | 2,81E-05 | 2,84E-03 | RSAD2, IFIT1, MX1, DDX58, OAS3, EIF2AK2 |
| hsa04110 | Cell cycle | 1,17E-04 | 5,89E-03 | E2F5, CCNB1, RAD21, CCNB2, BUB1 |
| hsa05164 | Influenza A | 5,08E-04 | 1,71E-02 | RSAD2, MX1, DDX58, OAS3, EIF2AK2 |
| hsa04114 | Oocyte meiosis | 1,57E-03 | 3,96E-02 | CALML3, CCNB1, CCNB2, BUB1 |
| hsa05162 | Measles | 2,07E-03 | 4,17E-02 | MX1, DDX58, OAS3, EIF2AK2 |