Table 2.
KEGG pathways that are significantly enriched with genes associated with PFS in castration-resistant prostate cancer (CRPC).
| KEGG ID | Pathway name | Enrichment p-value | Enrichment FDR | Genes |
|---|---|---|---|---|
| Enriched with upregulated genes | ||||
| hsa04610 | Complement and coagulation cascades | 8,14E-05 | 1,88E-02 | CPB2, SERPIND1, CFI, VTN, KNG1, SERPING1, SERPINA1, C3 |
| hsa00982 | Drug metabolism – cytochrome P450 | 1,45E-04 | 1,88E-02 | ADH6, ADH1B, CYP3A4, CYP2E1, CYP2C8, GSTP1 |
| Enriched with downregulated genes | ||||
| hsa05202 | Transcriptional misregulation in cancer | 3,28E-03 | 3,65E-01 | HIST1H3C, TAF15, ASPSCR1, NCOR1, EYA1 |
| hsa04390 | Hippo signaling pathway | 1,04E-02 | 5,17E-01 | BMP4, TGFB2, BMP5, NKD1 |
| hsa04350 | TGF-beta signaling pathway | 1,45E-02 | 5,17E-01 | BMP4, TGFB2, BMP5 |