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Hypothetic working model of regulating anti-TB protective immune paradigm via manipulating commensal bacteria-governed miRNA expression. Aberration of gut microbiota provokes susceptibility to TB and increases miR-21-3p expression not only in the cecum but also in the lungs during M. tuberculosis infection, in turn targeting IFN-γ. Exogenous miR-21-3p directly targets IFN- mRNA, in turn contributes to TB pathogenesis.
