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. 2019 Oct 9;31(1):103–111. doi: 10.1177/1120672119878044

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — (a) Mean percentage change in diurnal IOP from baseline at Week 6 (full analysis set), (b) mean change in IOP from baseline at 11:00 (peak) and 09:00 (trough) time points at Week 6 (full analysis set), and (c) mean percentage change in IOP from baseline at 11:00 (peak) and 09:00 (trough) time points at Week 6 (full analysis set).

n: number of patients with non-missing values of diurnal IOP change and any of the other covariates in the model at the corresponding time point of interest; BBFC: brinzolamide 1% and brimonidine 0.2% fixed-dose combination; CI: confidence interval; IOP: intraocular pressure; LS: least squares; SE: standard error; PGA: prostaglandin analog.