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. 2021 Jan 21;11:609935. doi: 10.3389/fphys.2020.609935

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Copyright © 2021 Weaver, Skinner, Furlong, Lucas, Cable, Rendeiro, McGettrick and Lucas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood plasma samples were taken were taken during seated rest (Rest); immediately after the first interval exercise bout (Ex 1; HIIT and SIT only); at the end of exercise (Ex 4); end of active recovery (Active)’ and end of passive recovery (Passive). Brain-derived neurotrophic factor (BDNF; n = 21, 7 female) was analyzed by ELISA. Data are presented as mean ± SD. Significance (analyzed by linear mixed model, p < 0.05) between resting values and subsequent time points is denoted by *. Significant differences between sexes at a given time point are denoted by ^§. M, Male; F, Female; ND, not determined.