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. 2021 Feb 4;176:1–12. doi: 10.1016/j.ijbiomac.2021.02.012

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© 2021 Published by Elsevier B.V.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 5 — Inhibitory screening of active compounds against SARS-CoV-2 3CLpro using FRET protease assay. (A) Ebselen. (B) Epigallocatechin-3-gallate. (C) Naringenin. (D) Kaempferol. (E) Quercetin. (F) Luteolin. Dose–response curves for IC50 values were determined by nonlinear regression. All data are shown as mean ± s.e.m., n = 3 biological replicates.