. 2021 Jan;9(1):54. doi: 10.21037/atm-20-3130

Table 2. Univariate cox regression analysis of OS for patients with surgically resected pCCA in the training cohort.

Characteristics	Univariate analysis
Characteristics	HR	95% CI	P value
Age (year)			<0.001***
<65	Reference
≥65	1.365	1.157–1.610	<0.001***
Race			0.598
White	Reference
Black			0.564
Other			0.386
Sex			0.502
Male	Reference
Female			0.502
Histology			0.014*
Adenocarcinoma and CCA	Reference
Other	0.744	0.587–0.942	0.014*
Grade			0.011*
I	Reference
II	1.024	0.794–1.321	0.854
III	1.352	1.037–1.762	0.026*
IV	0.934	0.43–2.029	0.863
AJCC T 6^th stage			<0.001***
T1	Reference
T2	1.839	1.364–2.479	<0.001***
T3	2.038	1.526–2.723	<0.001***
T4	2.849	2.054–3.953	<0.001***
AJCC M 8^th stage			0.005**
M0	Reference
M1	1.713	1.179–2.489	0.005**
AJCC N 7^th stage			<0.001***
N0	Reference
N1	2.054	1.746–2.415	<0.001***
N2	1.941	1.109–3.387	0.020*
AJCC N 8^th stage			<0.001***
N0	Reference
N1	1.844	1.55–2.194	<0.001***
N2	2.921	2.3–3.71	<0.001***
LODDS			<0.001***
LODDS1	Reference
LODDS2	1.826	1.518–2.198	<0.001***
LODDS3	2.683	2.19–3.289	<0.001***
LNR			<0.001***
LNR1	Reference
LNR2	1.871	1.532–2.285	<0.001***
LNR3	2.443	2.017–2.96	<0.001***
Radiation			0.001**
Yes	Reference
No/unknown	1.35	1.136–1.604	0.001**
Chemotherapy			0.004**
Yes	Reference
No/unknown	1.262	1.075–1.481	0.004**
Tumor size (cm)			<0.001***
<1.7	Reference
1.7–3.3	1.277	1.05–1.553	0.014
≥3.3	1.482	1.217–1.805	<0.001***

*, P<0.05; **, P<0.01; ***, P<0.001. OS, overall survival; pCCA, perihilar cholangiocarcinoma; HR, hazard ratio; CI, confidence interval; CCA, cholangiocarcinoma; AJCC, American Joint Committee on Cancer; TNM, tumor-node-metastasis; LODDS, log odds of positive lymph nodes; LNR, lymph node ratio.