Table 4. Multivariate cox regression analysis of OS for patients with surgically resected pCCA in the training cohort.
| Characteristics | Univariate analysis | ||
|---|---|---|---|
| HR | 95% CI | P value | |
| Age (year) | 0.001** | ||
| <65 | Reference | ||
| ≥65 | 1.323 | 1.115–1.57 | 0.001** |
| Histology | 0.119 | ||
| Adenocarcinoma and CCA | Reference | ||
| Other | 0.119 | ||
| Grade | 0.204 | ||
| I | Reference | ||
| II | 0.167 | ||
| III | 0.038 | ||
| IV | 0.442 | ||
| AJCC 6th T stage | <0.001*** | ||
| T1 | Reference | ||
| T2 | 1.609 | 1.183–2.187 | <0.001*** |
| T3 | 1.685 | 1.251–2.271 | <0.001*** |
| T4 | 1.908 | 1.348–2.7 | <0.001*** |
| AJCC 8th M stage | 0.664 | ||
| M0 | Reference | ||
| M1 | 0.664 | ||
| LODDS | <0.001*** | ||
| LODDS1 | Reference | ||
| LODDS2 | 1.709 | 1.41–2.071 | <0.001*** |
| LODDS3 | 2.668 | 2.136–3.333 | <0.001*** |
| Radiation | 0.019* | ||
| Yes | Reference | ||
| No/unknown | 1.29 | 1.044–1.594 | 0.019* |
| Chemotherapy | 0.008** | ||
| Yes | Reference | ||
| No/unknown | 1.29 | 1.044–1.594 | 0.008** |
| Tumor size (cm) | 0.028* | ||
| <1.7 | Reference | ||
| 1.7–3.3 | 1.09 | 0.893–1.33 | 0.398 |
| ≥3.3 | 1.326 | 1.082–1.624 | 0.006** |
*, P<0.05; **, P<0.01; ***, P<0.001. OS, overall survival; pCCA, perihilar cholangiocarcinoma; HR, hazard ratio; CI, confidence interval; CCA, cholangiocarcinoma; AJCC, American Joint Committee on Cancer; TNM, tumor-node-metastasis; LODDS, log odds of positive lymph nodes.