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. 2021 Jan;9(1):42. doi: 10.21037/atm-20-1013

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CMTM8 knockdown inhibits pancreatic cancer metastasis in vivo. (A) CMTM8-depleted and control PANC-1 cells were inoculated to nude mice via the tail vein, and lung metastasis was analyzed by in vivo bioluminescence imaging. (B) Quantification of metastatic lesions (n=6 mice per group). (C) Representative hematoxylin and eosin stained sections of the lung with metastatic nodules. Scale bar =50 µm. (D) Determination of the numbers of metastatic nodules in the lung. *P<0.05. (E) Immunohistochemical analysis of CMTM8 in 64 pairs of pancreatic cancer and adjacent noncancerous pancreatic tissues. Right panels show semi-quantitative analysis of CMTM8 staining. Scale bar =100 µm.