Table 2. Prognostic factors for overall survival in breast cancer patients (N=5,146).

Characteristics	Univariate			Multivariate
	HR (95% CI)	P		HR (95% CI)	P
Age, years
<50	Reference			Reference
50–70	1.64 (1.47–1.83)	<0.001*		1.49 (1.34–1.67)	<0.001*
>70	2.35 (2.06–2.68)	<0.001*		1.92 (1.67–2.2)	<0.001*
Race
Black	Reference			Reference
White	0.71 (0.64–0.79)	<0.001*		0.77 (0.69–0.86)	<0.001*
Other	0.64 (0.53–0.77)	<0.001*		0.75 (0.62–0.91)	0.003*
Tumor size
<8 cm	Reference			Reference
>8 cm	1.43 (1.24–1.64)	<0.001*		1.43 (1.24–1.65)	<0.001*
Unknown	1.6 (1.44–1.77)	<0.001*		1.46 (1.31–1.63)	<0.001*
Grade
I	Reference			Reference
II	1.03 (0.87–1.21)	0.769		1.14 (0.96–1.35)	0.134
III	1.42 (1.2–1.68)	<0.001*		1.63 (1.37–1.94)	<0.001*
IV	2.61 (1.48–4.59)	0.001*		2.48 (1.4–4.38)	0.002*
Unknown	1.41 (1.18–1.68)	<0.001*		1.15 (0.96–1.38)	0.124
Subtype
HER2 positive	Reference			Reference
LuminalA	1.51 (1.19–1.92)	0.001*		1.29 (1.01–1.64)	0.043*
LuminalB	1.1 (0.85–1.43)	0.462		1.06 (0.81–1.37)	0.681
TNBC	4.36 (3.36–5.65)	<0.001*		3.99 (3.08–5.19)	<0.001*
Surgery
No	Reference			Reference
Yes	0.54 (0.49–0.59)	<0.001*		0.58 (0.52–0.65)	<0.001*
Radiation
No	Reference			Reference
Yes	0.63 (0.57–0.7)	<0.001*		0.91 (0.81–1.03)	0.129
Chemotherapy
No	Reference			Reference
Yes	0.66 (0.61–0.72)	<0.001*		0.7 (0.64–0.77)	<0.001*

Values are expressed as hazard ratios (HR) with 95% confidence intervals unless otherwise indicated. *, Two-sided P values <0.05.