Table 3. Multivariate Cox analysis of overall and cancer-specific survival for 311 patients with RLNM.
| Variables | Overall survival | Cancer-specific survival | |||
|---|---|---|---|---|---|
| HR (95% CI)† | P | HR (95% CI) | P | ||
| Age, years | |||||
| <30 | Reference | Reference | |||
| 30–60 | 2.067 (1.439, 2.971) | <0.001 | 1.881 (1.259, 2.809) | 0.002 | |
| >60 | 2.133 (1.462, 3.112) | <0.001 | 1.474 (0.948, 2.293) | 0.085 | |
| Sex | |||||
| Female | Reference | Reference | |||
| Male | 1.277 (0.953, 1.713) | 0.102 | 1.255 (0.896, 1.757) | 0.187 | |
| Race | |||||
| Black | Reference | Reference | |||
| White | 0.622 (0.410, 0.946) | 0.026 | 0.654 (0.404, 1.060) | 0.085 | |
| Others | 0.330 (0.171, 0.636) | 0.001 | 0.337 (0.160, 0.707) | 0.004 | |
| Grade | |||||
| Low grade‡ | Reference | Reference | |||
| High grade§ | 1.522 (0.952, 2.432) | 0.079 | 1.705 (0.975, 2.981) | 0.061 | |
| Unknown | 0.637 (0.395, 1.027) | 0.064 | 0.620 (0.350, 1.101) | 0.103 | |
| Primary site | |||||
| Spine and pelvis | Reference | Reference | |||
| Extremities | 1.244 (0.864, 1.791) | 0.24 | 1.351 (0.902, 2.025) | 0.145 | |
| Skull, face and mandible | 1.262 (0.851, 1.872) | 0.247 | 1.160 (0.734, 1.832) | 0.525 | |
| Distant metastasis | |||||
| No | Reference | Reference | |||
| Yes | 2.018 (1.477, 2.756) | <0.001 | 2.448 (1.702, 3.522) | <0.001 | |
| Tumor size | |||||
| <6 cm | Reference | Reference | |||
| 6–12 cm | 1.207 (0.796, 1.831) | 0.376 | 1.121 (0.693, 1.815) | 0.641 | |
| >12 cm | 1.160 (0.755, 1.783) | 0.498 | 1.143 (0.704, 1.855) | 0.589 | |
| Unknown | 1.228 (0.796, 1.892) | 0.353 | 1.010 (0.603, 1.693) | 0.969 | |
| Tumor type | |||||
| Ewing sarcoma | Reference | Reference | |||
| Chondrosarcoma | 1.540 (1.011, 2.345) | 0.044 | 1.377 (0.877, 2.163) | 0.165 | |
| Osteosarcoma | 1.627 (0.914, 2.896) | 0.098 | 1.664 (0.884, 3.135) | 0.115 | |
| Other sarcomas | 1.832 (1.187, 2.828) | 0.006 | 1.544 (0.961, 2.481) | 0.072 | |
| Radiotherapy | |||||
| No | Reference | Reference | |||
| Yes | 0.876 (0.604, 1.270) | 0.485 | 1.028 (0.674, 1.567) | 0.9 | |
| Surgery | |||||
| No | Reference | Reference | |||
| Yes | 0.443 (0.307, 0.638) | <0.001 | 0.383 (0.253, 0.581) | <0.001 | |
†, HR, hazard ratio; CI, confidence interval. ‡, well or moderately differentiated. §, poorly differentiated or undifferentiated. RLNM, regional lymph node metastasis.