Table 1.
Differences in demographic characteristics, plasma apoCs levels, and CSF apoCs levels among APOE subgroups
| E2/E3 (N=5) | E2/E4 (N=2) | E3/E3 (N=27) | E3/E4 (N=16) | E4/E4 (N=11) | Total (N=61) | P-value | |
|---|---|---|---|---|---|---|---|
| Age | 0.042a | ||||||
| Mean (SD) | 66.8 (6.4) | 73.5 (2.1) | 67.7 (6.9) | 63.6 (5.6) | 61.9 (7.7) | 65.7 (7.0) | |
| Sex | 0.241 | ||||||
| female | 3 (60%) | 2 (100%) | 17 (63%) | 6 (38%) | 8 (73%) | 36 (59%) | |
| male | 2 (40%) | 0 (0%) | 10 (37%) | 10 (63%) | 3 (27%) | 25 (41%) | |
| Ethnicity | 0.510 | ||||||
| Hispanic/Latinos | 0 (0%) | 0 (0%) | 3 (11%) | 4 (25%) | 1 (9%) | 8 (13%) | |
| Not Hispanic/Latinos | 5 (100%) | 2 (100%) | 24 (89%) | 12 (75%) | 10 (91%) | 53 (87%) | |
| BMI | 0.700 | ||||||
| Median (IQR) | 27.4 (4.8) | 24.0 (NA) | 26.8 (5.7) | 25.5 (4.7) | 24.4 (3.7) | 25.4 (5.5) | |
| Years of Education | 0.658 | ||||||
| Median (IQR) | 16.0 (1.0) | 15.0 (3.0) | 17.5 (2.8) | 16.5 (4.5) | 17.0 (2.0) | 17.0 (3.0) | |
| CDR | 0.690 | ||||||
| 0 | 4 (100%) | 2 (100%) | 22 (88%) | 12 (75%) | 8 (73%) | 48 (83%) | |
| 0.5 | 0 (0%) | 0 (0%) | 2 (8%) | 4 (25%) | 3 (27%) | 9 (16%) | |
| 1 | 0 (0%) | 0 (0%) | 1 (4%) | 0 (0%) | 0 (0%) | 1 (2%) | |
| CSF ApoC-I (ng/ml) | 0.731 | ||||||
| Median (IQR) | 106 (57) | 96 (64) | 153 (115) | 169 (120) | 200 (50) | 158 (115) | |
| CSF ApoC-II (ng/ml) | 0.650 | ||||||
| Median (IQR) | 15 (11) | 25 (4) | 21 (14) | 19 (7) | 15 (6) | 20 (13) | |
| CSF ApoC-III (ng/ml) | 0.804 | ||||||
| Median (IQR) | 109 (31) | 81 (40) | 69 (69) | 76 (37) | 67 (16) | 79 (53) | |
| Plasma ApoC-I (μg/ml) | 0.641 | ||||||
| Mean (SD) | 116 (12) | 133 (15) | 113 (22) | 109 (20) | 111 (21) | 113 (20) | |
| Plasma ApoC-II (μg/ml) | 0.320 | ||||||
| Median (IQR) | 6.73 (2.32) | 10.37 (4.43) | 7.02 (8.45) | 7.71 (3.29) | 12.40 (9.92) | 7.36 (7.99) | |
| Plasma ApoC-III (μg/ml) | 0.043b | ||||||
| Median (IQR) | 198 (13) | 161 (4) | 107 (63) | 136 (42) | 136 (44) | 130 (73) |
a
no significant TukeyHSD pairwise comparisons
b
significant TukeyHSD pairwise comparison for Ɛ3/Ɛ3- Ɛ2/Ɛ3 (P adj = 0.022)