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Cytokine production after LPS injection. WT (n = 8) and CETPTg (n = 7) mice were iv injected with purified LPS from E. coli O55:B5 (1.0 mg/kg BW). Plasma levels of IL-6 (A), IL-10 (B), MIP-2 (C), IL-1β (D), MCP-1 (E), IFNγ (F) and TNFα (G) were measured using Luminex assay. Liver mRNA levels of IL-1β were determined 24 h after LPS injection. Data are means ± SD. ∗∗P < 0.01, ∗∗∗P < 0.001, WT versus CETPTg; Mann-Whitney test. n.s., nonsignificant.
