Table 4.
Association of the baseline characteristics and # of injections with t1/2app in CAB participants
| Simple Linear Regression | Multivariable Linear Regression | |||||
|---|---|---|---|---|---|---|
| fold-change | 95% CI | P-value | fold-change | 95% CI | P-value | |
| Sex at birth (female vs. male) | 1·33 | (1·06, 1·68) | 0·014 | 1·32 | (1·02, 1·69) | 0·035 |
| BMI (≥median* vs. <median*) | 1·31 | (1·06, 1·63) | 0·015 | 1·33 | (1·06, 1·67) | 0·016 |
| Age | 1·00 | (0·99, 1·01) | 0·759 | 1 | (0·99, 1·01) | 0·834 |
| Weight+ (kg) | 1·01 | (1·00, 1·01) | 0·104 | - | - | - |
| Race (non-Hispanic White as reference) | ||||||
| Hispanic | 1·11 | (0·82, 1·50) | 0·490 | 1·07 | (0·71, 1·63) | 0·742 |
| Non-Hispanic Asian | 1·11 | (0·40, 2·45) | 0·971 | 1·1 | (0·44, 2·75) | 0·846 |
| Non-Hispanic Black | 1·30 | (0·99, 1·72) | 0·059 | 1·42 | (0·95, 2·11) | 0·086 |
| Non-Hispanic Others | 0·91 | (0·50, 1·67) | 0·767 | 0·92 | (0·5, 1·68) | 0·784 |
| Region (US as reference) | ||||||
| Sub-Saharan Africa | 1·23 | (0·95, 1·59) | 0·110 | 1·08 | (0·69, 1·69) | 0·741 |
| Brazil | 1·11 | (0·83,1·50) | 0·473 | 0·81 | (0·54, 1·22) | 0·317 |
| Current Smoker (Yes vs. No) | 0·80 | (0·56,1·13) | 0·204 | 0·83 | (0·58, 1·19) | 0·317 |
| # of Injections | ||||||
| Cohort 1 | 1·09 | (0·88, 1·35) | 0·423 | 1·12 | (0·9, 1·38) | 0·316 |
| Cohort 2 | 0·88 | (0·69, 1·12) | 0·290 | 0·97 | (0·76, 1·24) | 0·785 |
| Cohort (2 vs 1) | 1·02 | (0·82, 1·28) | 0·851 | 1·61 | (0·43, 6·05) | 0·481 |
*
Median BMI was 27·2 for females and 25·0 for males.
+
Weight was not included in the multivariable linear regression due to the collinearity between weight and BMI.