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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: Curr Opin Crit Care. 2016 Aug;22(4):325–331. doi: 10.1097/MCC.0000000000000330

Table 1.

Summary of the main effects of various pharmacologic interventions to alter the hypermetabolic response to burn injury

Drug Inflammatory
response		 Stress
hormones		 Body
composition		 Net protein balance Insulin resistance/glucose metabolism Cardiac work
rhGH Improved No difference Improved No difference Hyperglycemia No difference
IGF-1 Improved No difference Improved Improved Improved No difference
Oxandrolone Improved No difference Improved Improved No difference No difference
Insulin Improved No difference Improved Improved Improved No difference
Fenofibrate No difference No difference No difference No difference Improved No difference
GLP-1 Unknown Unknown Unknown Unknown Improved (indirect) Unknown
Metformin Improved Unknown Unknown Improved Improved Unknown
Propranolol Improved Improved Improved Improved Improved Improved
Ketoconazole Unknown Improved Unknown Unknown Unknown Unknown
rhGH + propranolol Improved Improved Improved Improved Improved Improved
Oxandrolone + propranolol Improved (preliminary) Improved (preliminary) Improved (preliminary) Improved (preliminary) Improved (preliminary) Improved (preliminary)

GLP-1, glucagon-like peptide 1; IGF-1, insulin-like growth factor 1; rhGH, recombinant human growth hormone. Adapted from[20,24–26,42,45,51,53,54,61,63]and previously published in[21].