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. 2021 Feb 4;25:48. doi: 10.1186/s13054-021-03474-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a Plasma angiopoietin-2 levels were significantly associated with severity of AKI. b Patients requiring renal replacement therapy (RRT) had significantly higher plasma angiopoietin-2 levels than those not requiring RRT during hospitalization. Higher plasma angiopoietin-2 levels by quartile were significantly associated with positive fluid balance c on enrollment day, d in the subsequent 24 h, e 48 h and f 72 h since enrollment. Data in panels a–f were summarized as boxplots where box encompassed 25‒75th percentile, error bars encompassed 10‒90th percentile and horizontal line showed median. Groups were compared by Kruskal–Wallis test (panels a and c–f) or Mann–Whitney U test (panel b). Post hoc analysis of groups comparison was performed using Mann–Whitney U test and Bonferroni correction (panel a)