Table 1.
Clinical characteristics of 228 critically ill ICU patients with severe sepsis
| Severe AKI (n = 141) | No severe AKI (n = 87) | p value | |
|---|---|---|---|
| Age (years) | 56 [45–65] | 55 [46–66] | 0.945 |
| Male | 78 (55) | 39 (45) | 0.135 |
| APACHE II | 35 [30–39] | 30 [26–32] | < 0.001 |
| Creatinine (mg/dl) | 2.03 [1.29–3.74] | 0.93 [0.75–1.21] | < 0.001 |
| Ever smoker | 87 (62) | 53 (61) | 1.000 |
| Chronic kidney disease | 27 (19) | 10 (12) | 0.143 |
| Hepatic failure | 52 (37) | 22 (25) | 0.081 |
| Coagulation failure | 50 (36) | 14 (16) | 0.001 |
| Vasopressor use | 90 (64) | 38 (44) | 0.004 |
| ARDS development | 69 (49) | 42 (48) | 1.000 |
| Primary site of infection | |||
| Lung | 60 (43) | 54 (62) | 0.006 |
| Abdomen | 18 (13) | 5 (6) | 0.113 |
| Urogenital tract | 17 (12) | 6 (7) | 0.261 |
| Skin/soft tissue/bone | 10 (7) | 0 (0) | 0.015 |
| Endocarditis/catheter | 9 (6) | 10 (11) | 0.218 |
| CNS/sinus | 9 (6) | 7 (8) | 0.790 |
| Unclear and others | 18 (13) | 5 (6) | 0.113 |
| Ventilator-free days | 9 [0–23] | 23 [11–26] | < 0.001 |
| ICU days | 8 [5–11] | 7 [4–11] | 0.438 |
| Hospital days | 13 [8–22] | 11 [8–22] | 0.416 |
| Died in hospital | 63 (45) | 20 (23) | 0.001 |
ICU, intensive care unit; AKI, acute kidney injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, acute respiratory distress syndrome
Chronic kidney diseases are based on the medical records
Hepatic failure and coagulation failure are defined by Brussels organ failure scores
Continuous data are expressed as median with interquartile range [IQR], and categorical data are expressed as number of patients (%). p value is analyzed by Chi-square test (gender, smoking history, chronic kidney disease, primary site of infection, hepatic failure, coagulation failure, vasopressor use, ARDS development, and mortality) or Mann–Whitney U test (age, APACHE II scores, creatinine, ventilator-free days, ICU days, and hospital days)