Table 2.

Univariate and multivariate logistic regression analyses of risk factors for severe AKI

	Univariate		Simplified model using backward LR elimination method^a
	OR (95% CI)	p value	AOR (95% CI)	p value
Male	1.52 (0.89–2.61)	0.124	_^a
Age	1.00 (0.98–1.02)	0.993
Chronic kidney disease	1.82 (0.84–3.98)	0.132	_^a
Vasopressor use	2.28 (1.32–3.93)	0.003	_^a
Pulmonary sepsis	0.45 (0.26–0.78)	0.004	_^a
Hepatic failure	1.73 (0.96–3.12)	0.071	_^a
Coagulation failure	2.87 (1.47–5.59)	0.002	1.99 (0.90–4.42)	0.089
APACHE II	1.26 (1.17–1.35)	< 0.001	1.24 (1.15–1.34)	< 0.001
Angiopoietin-2 (per log increase)	8.81 (3.88–20.01)	< 0.001	6.07 (2.34–15.78)	< 0.001
Endocan (per log increase)	2.29 (1.34–3.91)	0.002	_^a
sVE-cadherin (per log increase)	11.87 (2.09–67.43)	0.005	_^a
Syndecan-1 (per log increase)	2.73 (1.32–3.93)	0.003	_^a

OR, odds ratio; CI, confidence interval; AOR, adjusted odds ratio

^aVariables that were entered into multivariate logistic regression analysis with backward LR elimination method did not retain the final model