Table 1.
The similarities and differences of biological characteristics in MSCs from different perinatal tissues
| Perinatal tissues | Similarities | Differences | |
|---|---|---|---|
| Umbilical cord and compartments [16] | Wharton’s jelly (WJMSCs) |
1. Adherence to plastic; 2. Positive for SSEA-3, SSEA-4, Tra-1-60, and Tra-1-81; 3. Adipogenic potential and levels of telomerase activity at passage 1. |
1. WJMSCs show significantly greater numbers in primary culture compared to other MSCs; 2. WJMSCs show significantly greater proliferation rates at passages 3, 5, and 10 compared to other MSCs; 3. The telomerase levels for WJMSCs were significantly greater than other MSCs at passage 10; 4. WJMSCs express significantly greater for CD29, CD44, CD73, HLA-ABC, CD24, CD108, OCT1, OCT4A, OCT4B, NANOG, and SOX2 compared to other MSCs; 5. WJMSCs and PVMSCs express significantly greater for CD146 and CD271 compared to other MSCs; 6. WJMSCs and PVMSCs express significantly less for fibroblast-related genes FAP, FSP, CD40, CD49d, and CD140b compared to other MSCs; 7. WJMSCs exhibit greater osteogenic and chondrogenic differentiation potential compared to other MSCs. |
| Amnion (AMSCs) | |||
| Subamnion (SAMSCs) | |||
| Perivascular (PVMSCs) | |||
| Mixed cord (UCMSCs) | |||
| Umbilical cord and membranes of the placenta [3] | Umbilical cord (UCMSCs) |
1. Adherence to plastic; 2. Positive for CD73, CD90, CD105, SOX2, and SSEA4 3. Negative for CD45, HLA-DR, CD34, and CD14; 4. Adipogenic, osteogenic, and chondrogenic differentiation potential. |
1. CPMSCs express greater for CD106 compared to other MSCs; 2. AMMSCs, CPMSCs, and UCMSCs were of fetal origin, and DPMSCs were of maternal origin; 3. UCMSCs show shorter population doubling time than other MSCs; 4. AMMSCs exhibit better capacity in the secretion of PGE2 and TGF-β1; 5. CPMSCs secrete higher level of HGF and VCAM-1; 6. DPMSCs release higher levels of VEGF and ANG-1. |
| Amniotic membrane (AMMSCs) | |||
| Chorionic plate (CPMSCs) | |||
| Decidua parietalis (DPMSCs) | |||
| Umbilical cord and amnion fluid [4] | Wharton’s jelly (WJMSCs) |
1. Adherence to plastic; 2. Growth characteristics at passage 5; 3. Positive for the expression of CD29, CD105, HLA-ABC, and OCT4; 4. Negative for CD34 and HLA-DR; 5. Myocardial-like cells differentiation capacity in vitro. |
1. AFMSCs show greater growth characteristics at passage 10 than WJMSCs. |
| Amnion fluid (AFMSCs) | |||
| Placenta and umbilical cord blood [7] | Placenta (PMSCs) |
1. Adherence to plastic; 2. Positive for the expression of CD44, CD73, CD90, CD105, and KLF4; 3. Negative for CD14, CD34, and CD45; 4. Growth characteristics; 5. Adipogenic, osteogenic, and chondrogenic differentiation potential; 6. Immunomodulatory effects. |
1. PMSCs are positive for the expression of NANOG; 2. UCBMSCs are positive for expression of MYC. |
| Umbilical cord blood (UCBMSCs) | |||