Figure 1.

Eps8 structure diagram. Computer analysis predicts that human Eps8 is 821 amino acids long, from N-terminal to C-terminal including: A PTB region (amino acids: 60–197), an EGFR-binding region (amino acids: 298–362), two proline-rich sequences (amino acids: 421–440 and 615–651), an SH3 domain (amino acids: 535–586), a SAM-PNT domain (amino acids: 709–783), and an ‘effector region’ (amino acids: 648–821). The blue bar indicates the functional region of Eps8 (38). Eps8, epidermal growth factor receptor pathway substrate 8.