Table 1. Summary of the Characteristic FTIR Peaks Representing the Key Functional Groups in Metformin Hydrochloride and Various Lipophilic Metformin Saltsa.
| metformin/metformin salts | metformin–NH2 | carbonyl group C=O | imine C=N stretch | N–H bending | C–N stretch |
|---|---|---|---|---|---|
| metformin | 3368.17 and 3294.06 | 1622.87 | 1544.76 | 1059.73 | |
| metformin–docusate | 3346.99 | 1734.72 | 1639.26 | 1558.26 | 1035.63 |
| metformin–oleate | 3368.20 | 1737.62 | 1623.43 | 1560.19 | 1040.22 |
| metformin–caprate | 3361.46 | 1737.62 | 1641.19 | 1553.44 | 1047.20 |
| metformin–laurate | 3369.17 | 1731.83 | 1640.23 | 1554.41 | 1052.98 |
| metformin–cholate | 3368.20 | 1736.65 | 1651.80 | 1579.48 | 1079.98 |
The characteristic FTIR peaks of metformin show considerable shifts in the lipophilic salts of metformin, indicating the formation of metformin salts.