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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: J Clin Neurophysiol. 1997 Jan;14(1):2–31. doi: 10.1097/00004691-199701000-00002

FIG. 1.

FIG. 1.

Sensitization of a “silent” C-nociceptor supplying the knee joint. A and B: Left: Absence of responses to flexion of the knee or to innocuous (OR) and noxious (n.OR) outward rotation of the knee in a cat before initiation of experimental arthritis by injection of kaolin and carrageenan into the knee joint. At this time, no receptive field could be demonstrated in the joint by mechanical probing (C: Left). Middle (A-C): A response to flexion and noxious outward rotation of the knee and a receptive field to probing the joint developed by 90 min after initiation of inflammation. The responses continued to increase (A and B: Right). The response to stimulation of the receptive field is shown in C (right). (Reprinted fromSchaible and Schmidt, 1988, with permission.)