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. 2021 Jan 26;13(1):1–29. doi: 10.4252/wjsc.v13.i1.1

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Outline of the production of humanized organs in livestock by chimera formation. OCT4: Octamer-binding transcription factor 4; SOX2: Sex determining region Y-box 2; KLF4: Kruppel-like factor 4; c-MYC: MYC Proto-Oncogene; hiPSC: Human induced pluripotent stem cells; piPSC: Porcine induced pluripotent stem cells; IR: Induced reprogramming; KO cells: Knock-out cells; SCNT: Somatic cell nuclear transfer.