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. 2020 Dec 30;45(3):975–986. doi: 10.3892/or.2020.7916

Figure 4.

Figure 4.

Effects of GW9662 and siPPARγ on the VSP-17-induced inhibition of migration and invasion in MDA-MB-231 and MDA-MB-453 cells. (A and B) Cells were treated with 1 µM GW9662, 10 µM VSP-17 or 10 µM VSP-17 + 1 µM GW9662 for 24 h. Transwell assays were used to evaluate the (A) migratory and (B) invasive abilities of MDA-MB-231 and MDA-MB-453 cells. (C and D) Cells were treated with 10 µM VSP-17 and/or transfected with siPPARγ. Transwell assays were used to evaluate the (C) migratory and (D) invasive abilities of MDA-MB-231 and MDA-MB-453 cells. The data are expressed as the mean ± SEM of three independent experiments. **P<0.01 vs. control; &&P<0.01 vs. VSP-17. si, small interfering RNA; PPARγ, peroxisome proliferator-activated receptor γ.