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. 2021 Jan 14;45(3):1171–1181. doi: 10.3892/or.2021.7936

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Copyright: © Rashid et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — In vivo depletion of M1-macrophages, and increased number of M2-macrophages and gMDSCs by MDSC-derived exosome treatment. Normal Balb/c mice were treated with and without (control) splenic MDSC-derived exosomes for 1 week. Quantification of cells from the bone marrow (BM), lungs, and spleen showing (A) decreased number of M1-macrophages and increased M2-macrophages in the spleen and (B) decreased number of monocytic mMDSCs and increased number of granulocytic gMDSCs in the spleen following treatment with MDSC-derived exosomes. Quantitative data are expressed as mean ± SEM. *P<0.05, **P<0.01, n=4. MDSCs, myeloid-derived suppressor cells.