Table 2.
Correlation between clinical pathologic characteristics and AGLR level in HCC patients
| Variables | AGLR level | |||||
|---|---|---|---|---|---|---|
| Training cohort (n = 248) | Validation cohort (n = 247) | |||||
| ≤ 90 n (%) | > 90 n (%) | p value | ≤ 90 n (%) | > 90 n (%) | p value | |
| Age (years) | ||||||
| ≤ 60 | 92 (46.2) | 107 (53.8) | 0.347 | 81 (41.3) | 115 (58.7) | 0.815 |
| > 60 | 19 (38.8) | 30 (61.2) | 22 (43.1) | 29 (56.9) | ||
| Gender | ||||||
| Female | 18 (60.0) | 12 (40.0) | 0.073 | 18 (52.9) | 16 (47.1) | 0.152 |
| Male | 93 (42.7) | 125 (57.3) | 85 (39.9) | 128 (60.1) | ||
| Drinking | ||||||
| No | 62 (44.6) | 77 (55.4) | 0.958 | 58 (43.3) | 76 (56.7) | 0.583 |
| Yes | 49 (45.0) | 60 (55.0) | 45 (39.8) | 68 (60.2) | ||
| HBsAg | ||||||
| Negative | 14 (38.9) | 22 (61.1) | 0.444 | 17 (43.6) | 22 (56.4) | 0.794 |
| Positive | 97 (45.8) | 115 (54.2) | 86 (41.3) | 122 (58.7) | ||
| AFP (ng/mL) | ||||||
| ≤ 20 | 54 (62.8) | 32 (37.2) | < 0.001 | 43 (58.6) | 30 (41.4) | < 0.001 |
| > 20 | 57 (35.2) | 105 (64.8) | 60 (34.5) | 114 (65.5) | ||
| Liver cirrhosis | ||||||
| No | 8 (57.1) | 6 (42.9) | 0.337 | 10 (43.5) | 13 (56.5) | 0.856 |
| Yes | 103 (44.0) | 131 (56.0) | 93 (41.5) | 131 (58.5) | ||
| Tumor size (cm) | ||||||
| ≤ 5 | 66 (65.3) | 35 (34.7) | < 0.001 | 61 (56.5) | 47 (43.5) | < 0.001 |
| > 5 | 45 (30.6) | 102 (69.4) | 42 (30.2) | 97 (69.8) | ||
| Tumor number | ||||||
| Single | 90 (48.6) | 95 (51.4) | 0.035 | 84 (43.5) | 109 (56.5) | 0.272 |
| Multiple | 21 (33.3) | 42 (66.7) | 19 (35.2) | 35 (64.8) | ||
| TNM stage | ||||||
| I-II | 82 (68.9) | 37 (31.1) | < 0.001 | 81 (57.4) | 60 (42.6) | < 0.001 |
| III- IV | 29 (22.5) | 100 (77.5) | 22 (20.8) | 84 (79.2) | ||
| Microvascular invasion | ||||||
| No | 95 (52.2) | 87 (47.8) | < 0.001 | 96 (46.2) | 112 (53.8) | 0.001 |
| Yes | 16 (24.2) | 50 (75.8) | 7 (17.9) | 32 (82.1) | ||
| Recurrence | ||||||
| No | 70 (47.0) | 79 (53.0) | 0.388 | 71 (45.2) | 86 (54.8) | 0.138 |
| Yes | 41 (41.4) | 58 (58.6) | 32 (35.6) | 58 (64.4) | ||
AGLR, alkaline phosphatase plus gamma-glutamyl transpeptidase to lymphocyte ratio; HBsAg, hepatitis B surface antigen; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis