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. 2021 Feb 3;19:39. doi: 10.1186/s12957-021-02149-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MiR-197-3p is a target of hsa_circ_0025202. a qRT-PCR analysis of miR-197-3p expression in BC tissues and matched non-tumor tissues. b qRT-PCR analysis of miR-197-3p expression in normal MCF-10A cells, BC cell lines (T47D and MCF7) and TAM-resistant BC cell lines (T47D/TAM and MCF7/TAM). c The correlation between hsa_circ_0025202 level and miR-197-3p expression in BC tissues using the Pearson correlation analysis. d Sequence alignment of miR-197-3p with the putative binding sites in the wild-type regions of hsa_circ_0025202. e Luciferase activities detection in 293 T cells co-transfected with the reporter plasmids and indicated miRNAs using the dual-luciferase reporter assay. f qRT-PCR analysis of hsa_circ_0025202 and miR-197-3p levels in T47D and MCF7 cells after RIP assay. **P < 0.01, ***P < 0.001, ^#P < 0.05, ^###P < 0.001