. 2021 Jan 20;6(4):2824–2835. doi: 10.1021/acsomega.0c05138

Table 2. pK_a Values of Individual Nitrogen Atoms of Neamine Determined Using ¹H, ¹³C, and ¹H−¹⁵N HMBC NMR Spectroscopies in this Work (n = 2) and Compared with the Published Data, as Indicated^a^,^b^,^c.

pK_a values of individual nitrogen atoms of neamine determined using ¹H NMR spectroscopy in D₂O relative to the HDO peak at δ = 4.8 ppm, at 25 °C.²⁸

This work (n = 2).

The pK_a value of N-6′ of neamine determined using ¹H NMR spectroscopy (in this work) is the average pK_a of the values of N-6′ obtained using ¹H NMR spectroscopic data for H-6′a (8.33) and 6′b (8.35).

Table 2. pKa Values of Individual Nitrogen Atoms of Neamine Determined Using 1H, 13C, and 1H−15N HMBC NMR Spectroscopies in this Work (n = 2) and Compared with the Published Data, as Indicateda,b,c.

Table 2. pK_a Values of Individual Nitrogen Atoms of Neamine Determined Using ¹H, ¹³C, and ¹H−¹⁵N HMBC NMR Spectroscopies in this Work (n = 2) and Compared with the Published Data, as Indicated^a^,^b^,^c.