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. 2021 Feb 3;13:16. doi: 10.1186/s13073-021-00838-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — gSOS effectively stratifies cumulative fracture risk. a Lower gSOS is associated with a higher cumulative incidence of major osteoporotic fracture. b Comparison of the age-dependent predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident major osteoporotic fracture. c Lower gSOS is associated with a higher cumulative incidence of hip fracture. d Comparison of the age-dependent predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident hip fracture. All association tests were based on 4663 men from the MrOS US and 3615 women from the SOF cohorts using Cox proportional hazard models adjusted for sex. Only clinical risk factors available in both cohorts are presented. CIs of C-index were derived from 200 bootstrap replicates