Table 3.

Net reclassification improvement of fracture risk prediction using FRAX-gSOS

Cohort	UKB*	US§	SWE¶	SOF†	UKB	US	SWE	SOF
	Major osteoporotic fracture				Hip fracture
\Categorical NRI (95% CI)	0.028 (0.016–0.039)	0.043 (0.020–0.066)	0.072 (0.027–0.118)	0.024 (− 0.008–0.056)	0.055 (0.009–0.100)	0.066 (0.025–0.107)	0.037 (− 0.012–0.085)	− 0.001 (− 0.034–0.031)
Continuous NRI (95% CI)	0.300 (0.245–0.354)	0.179 (0.092–0.267)	0.232 (0.116–0.348)	0.237 (0.155–0.318)	0.206 (0.073–0.339)	0.180 (0.060–0.300)	0.132 (− 0.045–0.310)	0.205 (0.116–0.295)
IDI (95% CI)	0.010 (0.008–0.011)	0.011 (0.008–0.015)	0.014 (0.009–0.019)	0.017 (0.012–0.021)	0.003 (0.001–0.005)	0.007 (0.003–0.011)	0.004 (− 0.002–0.011)	0.011 (0.007–0.015)

*The UK Biobank test dataset (N = 80,014)

^§The MrOS US cohort (N = 4663)

^¶The MrOS Sweden cohort (N = 1880)

^†The SOF cohort (N = 3615)