Table 3.

Meta-analytic methods used in the NICE public health intervention appraisals to synthesise the effectiveness evidence

Reference number	Articles	Evidence type	Quality grading of evidence	Includes RCTs only	Final outcome	Description of main outcome	Outcome measure statistic	Type of synthesis	M-A: Fixed or Random (F/R)	Lumping multiple interventions in comparison	Potential intervention components	Details of intervention components	Presentation of results	Assessed publication bias	Software
NG105	Evidence review 1: Multi-agency partnerships	E,CE	$✓$		$✓$	Suicide rate	RR	MA	nr	$✓$			Txt		nr
NG105	Evidence review 4: Information, advice, education and training	E,CE	$✓$		$✓$	Suicide attempts	RR / change in %	MA	nr	$✓$	$✓$	Components that provide information, advice, education for staff or public.	Txt		nr
NG105	Evidence review 6: Reducing access to means	E,CE	$✓$		$✓$	Suicide rate	IRR / difference in number	MA	nr	$✓$	$✓$	Physical barriers, surveillance, encouraging help-seeking.	T		nr
NG102	Evidence review 3: Offering behavioural support to promote health and wellbeing	E, CE, DM	$✓$		$✓$	Weight change	MD	MA	R	$✓$			FP/Txt		RevMan
NG103	Evidence review 2: Increasing flu vaccination uptake in children	E,CE	$✓$			Uptake of vaccinations	RR	MA	R				FP/Txt/T		RevMan
NG103	Evidence review 3: Increasing flu vaccination uptake in clinical risk groups	E,CE	$✓$			Uptake of vaccinations	RR	MA	R				FP/Txt/T		RevMan
NG103	Evidence review 4: Increasing flu vaccination uptake in health and social care staff	E,CE	$✓$			Uptake of vaccinations	RR	MA	R				FP/Txt/T		RevMan
NG92	Non NHS treatments for smoking cessation	E	$✓$	$✓$	$✓$	Smoking cessation	OR	MA	R				FP/Txt		Revman
NG58	Evidence review 3 - The effectiveness and efficiency of service delivery models for health, social care and voluntary and community sector organisations at meeting the needs of people with a severe mental illness who also misuse substances	E	$✓$	$✓$	$✓$	Mental and physical health outcomes (including mortality, recovery and relapse, physical morbidity)	RR	MA	R				FP/Txt		RevMan
NG55	Evidence review 2 - Assessment	E	$✓$		$✓$	Recidivism	Area under curve	MA	R				FP/Txt		R (meta-for)
NG48	Evidence review 1	E	$✓$		$✓$	Plaque index / gingival index	SMD	MA	R	$✓$	$✓$	Assessments of oral health, maintaining access to dental ser- vices, staff training, oral health education, providing oral health resources.	FP/Txt		Stata
NG44	Evidence review 2 - Community engagement 2015 - Brunton	E	$✓$		$✓$	Self-efficacy post test outcome	SMD	MA	R		$✓$	Community engage- ment components: coalitions, collabo- rations, stakeholder involvement, advisory groups or partnerships.	FP/Txt		Stata (metareg)
NG44	Evidence review 3 - Community engagement 2015 - Stokes	E	$✓$	$✓$	$✓$	Behavioural outcomes	SMD	MA	R				FP/Txt	$✓$	Stata (metareg)
Reference number	articles	Evidence type	Quality grading of evidence	Includes RCTs only	Final outcome	Description of main outcome	Outcome measure statistic	Type of synthesis	M-A: Fixed or Random (F/R)	Lumping multiple interventions in comparison	Potential intervention components	Details of intervention components	Presentation of results	Assessed publication bias	Software
PH54	Evidence review 1 - A systematic review and economic evaluation - a short report	E, CE	$✓$	$✓$		Physical activity (self-report or objectively monitored), physical fitness (e.g. maximal oxygen uptake (VO2max), health outcomes (e.g. blood pressure), adverse events (e.g. musculoskeletal injury), and uptake and adherence to ERS.	MD	MA	R		$✓$	Combination of coun- selling, written materi- als, supervised exercise training.	FP/Txt		RevMan
PH53	Evidence review 1a	E	$✓$	$✓$	$✓$	BOCF weight change	MD	MA	F	$✓$	$✓$	Multi-component weight management programmes.	FP/Txt		RevMan
PH53	Evidence review 1b	E	$✓$	$✓$	$✓$	BOCF weight change	MD	MA	R	$✓$	$✓$	Multi-component weight management programmes.	FP/Txt/T		nr
PH53	Evidence review 1c	E	$✓$	$✓$	$✓$	BOCF weight change	MD	MA	R	$✓$	$✓$	Multi-component weight management programmes.	FP/Txt/T		nr
PH48	Review 2 – Effectiveness of smoking cessation interventions in acute and maternity services	E	$✓$	$✓$	$✓$	Abstinence from smoking at least six months after the start of the intervention	OR	MA	F				FP/Txt		RevMan
PH48	Review 3 – Barriers & facilitators for smoking cessation interventions in acute and maternity services	E	$✓$		$✓$	Impact of stopping smoking shortly before surgery on surgery outcomes / complications	RR	MA	R				FP/Txt		RevMan
PH48	Review 4 – Effectiveness of smoking cessation interventions in mental health services	E	$✓$	$✓$	$✓$	Participants who made successful quit attempts	OR	MA	R	$✓$	$✓$	Pharmacological, psychological, be- havioural, or self-help intervention components	FP/Txt	$✓$	RevMan
PH47	Review of effectiveness and cost effectiveness	E, CE	$✓$	$✓$	$✓$	BMI, Zbmi	SMD	MA	R	$✓$	$✓$	Diet, physical activity, behaviour change inter- vention components.	FP/Txt	$✓$	Stata
PH44	Review of effectiveness and barriers and facilitators	E	$✓$		$✓$	Self-reported physical activity	Mean, RR	MA	R				FP/Txt		RevMan
PH38	Evidence reviews	E, CE, DM	$✓$	$✓$	$✓$	Progression to T2 Diabetes	Other	MA	R	$✓$			FP		RevMan
PH38	R2 systematic review and meta-analysis of lifestyle, pharmacological and surgical interventions	E	$✓$	$✓$	$✓$	Progression to T2 Diabetes	HR	MA and NMA	R	$✓$	$✓$	Lifestyle, drug, and sur- gical intervention com- ponents.	FP/Txt		RevMan

Notation: E: effectiveness, CE: cost-effectiveness, DM: decision model, RR: risk ratio, MD: mean difference, OR: odds ratio, SMD: standardised mean difference, HR: hazard ratio, MA: meta-analysis, NMA: network meta-analysis, nr: not reported, R: random effects, F: fixed effect, Txt: text, T: table, FP: forest plot