Fig. 3.

Decreased KAT6A expression inhibited Nrf2/ARE signaling pathway and led to ROS accumulation in OBMSCs. a The expressions of Nrf2 proteins in YBMSCs and OBMSCs were explored by western blot (n = 6). b The expressions of Nrf2 protein in YBMSCs that transfected with scrambled siRNA or KAT6A siRNA were explored by western blot (n = 3). c The expressions of Nrf2 protein in OBMSCs that transfected with vector or KAT6A plasmid were explored by western blot (n = 3). d The expressions of Nrf2, GCLC, and NQO1 in YBMSCs and OBMSCs were explored by qRT-PCR (n = 6). e The ROS level in YBMSCs and OBMSCs was explored (n = 6). f The expressions of Nrf2, GCLC, and NQO1 in YBMSCs that transfected with scrambled siRNA or KAT6A siRNA were explored by qRT-PCR (n = 3). g The ROS level in YBMSCs that transfected with scrambled siRNA or KAT6A siRNA was explored (n = 3). h The expressions of Nrf2, GCLC, and NQO1 in OBMSCs that transfected with vector or KAT6A plasmid were explored by qRT-PCR (n = 3). i The ROS level in OBMSCs that transfected with vector or KAT6A plasmid was explored (n = 3)