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. 2021 Feb 3;21:87. doi: 10.1186/s12935-020-01706-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The effect of LINC00963 on the proliferation of colon cancer cells. a The expression of LINC00963 was decreased after transfecting siLINC00963 into HCT116 cells. b The expression of LINC00963 was promoted after transfection of LOVO cells with the overexpression plasmid of LINC00963. c, d CCK-8 results showed that LINC00963 overexpression increased cell activity, while silencing LINC00963 decreased cell activity. e–h Clone formation experiment was used to detect the effect of LINC00963 up-regulation or down-regulation on colon cancer cell proliferation. ^***P < 0.001 vs siNC; ^{^^}P < 0.01, ^{^^^}P < 0.001vs NC