Fig. 9.

Effect of miR-532-3p targeting HMGA2 on invasion and migration-related proteins of CRC cells. a–d MiR-532-3p inhibitor and HMGA2 overexpression promoted cell invasion; miR-532-3p mimic and silent HMGA2 inhibited cell invasion. e–h The effects of miR-532-3p and HMGA2 on the expressions of MMP-3 and MMP-9 were determined by Western blot. GAPDH served as a control. The experiment was repeated three times independently. ^***P < 0.001 vs IC + siNC; ^###P < 0.001 vs I + siNC; ^{^^^}P < 0.001 vs IC + siHMGA2; ^&&&P < 0.001 vs MC + NC; ^△△△P < 0.001 vs MC + HMGA2; ⁺⁺⁺P < 0.001 vs M + NC