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. 2021 Feb 3;12:101. doi: 10.1186/s13287-021-02150-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Inhibiting miR-205 accelerates osteogenesis and remodeling during DO. A Gross observational result. B Histological analyses revealed that inhibiting miR-205 was able to accelerate new bone formation. C CBCT results from control, negative control, and miR-205 inhibitor groups following 0, 2, 3, and 4 weeks of consolidation. Few calluses were observed in the distraction gap at the end of the distraction phase (DO14) in these groups. The amount of mineralized callus increased over time, with more callus being evident in the miR-205 inhibited group. The distraction gap was fully bridged at the end of the consolidation phase (bar = 10 mm). D Quantitative analyses of CBCT results revealed that the Hounsfield unit (HU) values were significantly increased during DO and were higher in the miR-205 inhibition group relative to the other groups