Table 1:
Demographic characteristics of the study participants.
| Characteristic | All (N = 421) | CU (N = 296) | MCI (N = 69) | aDem (N = 56) |
|---|---|---|---|---|
| Study, no. (%) | ||||
| MCSA | 331 (79%) | 280 (95%) | 47 (68%) | 4 (7%) |
| ADRC | 90 (21%) | 16 (5%) | 22 (32%) | 52 (93%) |
| Age, years | ||||
| Median (IQR) | 70 (61, 78) | 69 (59, 76) | 77 (72, 86) | 68 (61, 77) |
| Min, Max | 34, 97 | 34, 90 | 46, 97 | 53, 89 |
| Sex, no. (%) | ||||
| Female | 187 (44%) | 128 (43%) | 30 (43%) | 29 (52%) |
| Male | 234 (56%) | 168 (57%) | 39 (57%) | 27 (48%) |
| Education, years | ||||
| Median (IQR) | 16 (13, 17) | 16 (14, 17) | 15 (12, 16) | 16 (13, 16) |
| Min, Max | 0, 25 | 8, 20 | 0, 21 | 12, 25 |
| APOE genotype, no. (%)* | ||||
| ε4 non-carrier | 261 (66%) | 202 (72%) | 44 (69%) | 15 (29%) |
| ε4 carrier | 134 (34%) | 77 (28%) | 20 (31%) | 37 (71%) |
| Short Test of Mental Status | ||||
| Median (IQR) | 36 (33, 37) | 37 (36, 38) | 32 (29, 33) | 22 (18, 28) |
| Min, Max | 5, 38 | 29, 38 | 24, 37 | 5, 36 |
| Amyloid PET, SUVR† | ||||
| Median (IQR) | 1.43 (1.33, 1.99) | 1.38 (1.31, 1.49) | 1.93 (1.40, 2.33) | 2.40 (2.17, 2.70) |
| Min, Max | 1.11, 3.63 | 1.11, 3.63 | 1.22, 3.30 | 1.46, 3.41 |
| Abnormal, no. (%) | 178 (42%) | 77 (26%) | 46 (67%) | 55 (98%) |
| Tau PET, SUVR† | ||||
| Median (IQR) | 1.20 (1.15, 1.29) | 1.18 (1.14, 1.23) | 1.25 (1.19, 1.38) | 1.94 (1.55, 2.32) |
| Min, Max | 0.94, 3.13 | 0.94, 1.57 | 0.99, 2.27 | 1.09, 3.13 |
| Abnormal, no. (%) | 138 (33%) | 55 (19%) | 32 (46%) | 51 (91%) |
APOE genotype was missing for 26 participants (17 CU, 5 MCI, and 4 aDem).
The amyloid and tau PET measures are derived meta-ROIs. The amyloid PET meta-ROI includes the prefrontal, orbitofrontal, parietal, temporal, anterior and posterior cingulate, and the precuneus. The tau PET meta-ROI includes the amygdala, entorhinal cortex, fusiform, parahippocampal, and inferior temporal and middle temporal gyri. Abnormal was defined as ≥ 1.48 SUVR for amyloid PET and ≥ 1.25 SUVR for tau PETCU = cognitively unimpaired; MCI = mild cognitive impairment; aDem = amnestic dementia; MCSA = Mayo Clinic Study of Aging; ADRC = Alzheimer’s Disease Research Center; SUVR = standardized uptake value ratio; IQR = interquartile range.