Figure 2.

Gene signature scores for extracranial metastases (blue), melanoma brain metastases (orange), and primary melanoma (red) samples from the University of Pittsburgh Medical Center craniotomy cohort. Results are shown as boxplots with median and 95% confidence intervals for each signature and tumor type. Asterisks indicate two-way comparisons that are statistically significant at a nominal p-value <0.05. Abbreviations: Th, T helper; Tcm, central memory T cells; Tem, effector memory T cells; TFH, follicular helper T cells; Tgd, γδT cells; TReg, regulatory T cells; NK, natural killer cells; Mac, macrophages; DC, dendritic cells; aDC, activated DCs; iDC, immature DCs; pDC, plasmacytoid DCs; EMT, epithelial-to-mesenchymal transition; LCK, lymphocyte-specific protein tyrosine kinase; IFN, interferon; TNF, tumor-necrosis factor; IL, interleukin.