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. 2021 Jan 21;10:604213. doi: 10.3389/fonc.2020.604213

Figure 4.

Figure 4

Expression of hypoxia-inducible factor-1 alpha (HIF1α), vascular endothelial growth factor A (VEGF-A), and basic fibroblast growth factor (bFGF) in melanoma brain metastases (MBM) from the University of North Carolina at Chapel Hill craniotomy cohort. (A) Representative tissue sections stained with immunohistochemistry. See Patients, Materials and Methods for details. Black circles indicate immune cell clusters. (B) Overall survival of patients with MBM according to the expression of HIF1α, VEGF-A, bFGF, and using optimal cut-point analysis. See Patients, Materials and Methods for details. (C) Expression (digital H-score) of HIF1α, VEGF-A, and bFGF within each of the four different compartments of MBM. The numbers above boxplots indicate the number of specimens for each measured variable. See Patients, Materials and Methods for details in the analysis. *p= 0.01-0.05; **p < 0.01.