FIG 1.

Animals (n = 16) were dosed with a three-dose (q48h) regimen of 20 (n = 8) or 5 (n = 8) mg/kg BCV via oral gavage, so that BCV pharmacokinetics could be determined following single (a, b) and repeat (c, d) dosing. An increase in concentrations of BCV with increased dose is seen. BCV plasma concentrations were generally below the limit of quantitation (1 ng/ml; BLQ values were not plotted) by 24 h following the 5-mg/kg dose (c) and by 48 h following the 20-mg/kg BCV dose (d). Data for female animals (F) are represented by filled blue symbols, and data for male animals (M) are represented by open red symbols. *, two animals (ID numbers 12054 and 13070) mistakenly received 20 mg/kg instead of 5 mg at the 48-h drug administration point.