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. Author manuscript; available in PMC: 2021 Feb 4.
Published in final edited form as: J Occup Environ Med. 2019 Dec;61(Suppl 12):S35–S44. doi: 10.1097/JOM.0000000000001669

FIGURE 2.

FIGURE 2.

Metabolic dose responses associated with exposure to BghiP and HpCDD. A, Unsupervised HCA-heatmap indicates that intensity of 720 metabolites drive the separation between the vehicle, 200 nM BghiP and 1 μM BghiP exposure. B, PCA plot showing separation of the vehicle (green) 200 nM BghiP (yellow) and 1 μM BghiP (red), through the 1st (19% variation) and 2nd (14% variation) principal components. C, Unsupervised HCA-heatmap indicates that intensity of 388 metabolites drive the separation between the vehicle, 200 pM HpCDD and 1 nM HpCDD exposure. D, PCA plot showing separation of the vehicle (green) 200 pM HpCDD (yellow) and 1 nM HpCDD (red), through the 1st (12% variation) and 2nd (10% variation) principal components. n=23 (BghiP 1 μM); n=24 (BghiP 200nM, vehicle, 200 pM HpCDD, and 1 nM HpCDD).