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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Mol Pharm. 2020 Sep 9;17(10):3794–3812. doi: 10.1021/acs.molpharmaceut.0c00562

Table 1.

FTC plasma pharmacokinetic parameters. Displayed are the FTC PK parameters for rats administered an i.v. bolus dose of 10 mg FTC equivalents/kg of PLS-FTC or FTC.

Parameter PLS-FTC Emtricitabine
C0 (ng/mL) 4901 ± 3621* 10610 ± 2947
Cmax (ng/mL) 3839 ± 1734* 5850 ± 853
T1/2 (h) 6.99 ± 2.62* 14.10 ± 5.17
AUCall (h*ng/mL) 11100 ± 3281* 6396 ± 1014
MRT (h) 3.64 ± 0.47* 1.80 ± 0.32
Cl (mL/h/kg) 1053 ± 620* 1600 ± 287
Vss (mL/Kg) 3816 ± 2254 2937 ± 1095

C0, concentration extrapolated to time zero; Cmax, maximum measured concentration; T1/2, elimination half-life; AUCall, area under the curve from time zero to the last measurable time point; MRT, mean residence time; Cl, clearance; Vss, volume of distribution at steady state. Data are presented as mean ± SD (n=8).

Asterisk (*) represents statistical significance, two-sided t-test, p < 0.05.