TABLE 3.

Q-Finder results on the detection of predictive factors describing patients with a higher risk than the others in experiencing hypoglycemia under Premixed insulin than under Basal insulin (with or without Prandial insulin).

Subgroup Ranking a	Subgroup description	Coverage Discovery/Test	Adjusted odds-ratios for differential treatment effect (IC95%) Discovery b	p-value for differential treatment effect Discovery	Adjusted odds-ratios for differential treatment effect (IC95%) Test b	p-value for differential treatment effect Test	Adjusted p-value for differential treatment effect Test c
S1	Statins for dyslipidemia = Yes AND Device used for insulin: Vials and syringes = No AND Total # of anti-diabetics agents $\le$ 1	28%/31%	3.04 [1.9; 5.0]	7.02E-6	2.12 [1.4; 3.2]	2.36E-4	1.18E-3
S2	Device used for insulin: Disposable pen = Yes AND Smoking habits = Never AND Total # of anti-diabetics agents $\le$ 1	25%/26%	3.31 [2.0; 5.6]	7.13E-6	1.93 [1.3; 2.9]	2.04E-3	4.28E-3
S3	Total # of anti-diabetics agents $\le$ 1 AND # of different devices used by the patient $\ge$ 1	48%/61%	2.71 [1.8; 4.2]	9.55E-6	2.59 [1.7; 4.0]	1.92E-5	1.92E-4
S4	Treated for other form of dyslipidemia = Yes AND Times seen by a diabetologist in the past 3 months $\le$ 1 AND Device used for insulin: Vials and syringes = No	33%/38%	3.55 [2.0; 6.3]	1.26E-5	1.93 [1.2; 3.0]	5.02E-3	7.17E-3
S5	Receives oral glycaemic lowering drugs = Yes AND Times seen by a diabetologist in the past 3 months = 0 AND Device used for insulin: Vials and syringes = No	29%/34%	2.98 [1.8; 4.9]	2.40E-5	1.86 [1.2; 2.8]	2.14E-3	4.28E-3
S6	Statins for dyslipidemia = Yes AND Total # of anti-diabetics agents $\le$ 1 AND Age at diagnosis (year) $\le$ 56	30%/33%	2.74 [1.7; 4.4]	2.64E-5	2.04 [1.4; 3.0]	4.08E-4	1.34E-3
S7	Treated for other form of dyslipidemia = Yes AND Times seen by a diabetologist in the past 3 months $\le$ 1 AND # of different devices used by the patient $\ge$ 1	33%/44%	3.37 [1.9; 6.0]	2.79E-5	2.05 [1.2; 3.4]	4.58E-3	7.17E-3
S8	Statins for dyslepidemia = Yes AND Device used for insulin: Vials and syringes = No AND HDL serum cholesterol (mg/dL) $\le$ 58.0	27%/30%	3.22 [1.9; 5.6]	2.82E-5	1.05 [0.7; 1.7]	8.21E-1	8.21E-1
S9	Statins for dyslipidemia = Yes AND Visits diabetes websites = No AND Duration of insulin therapy (year) $\ge$ 4	34%/32%	2.59 [1.7; 4.1]	3.12E-5	1.14 [0.8; 1.7]	5.09E-1	5.65E-1
S10	Other form of dyslipidemia = Yes AND Visits diabetes websites = No AND Duration of insulin therapy (year) $\ge$ 4	40%/37%	2.56 [1.6; 4.0]	3.22E-5	1.25 [0.9; 1.8]	2.48E-1	3.10E-1

^aSubgroup ranking is based on p-value for differential treatment effect on discovery dataset

^bOdds-ratios are adjusted for confounding factors through multiple regression model

^cAdjusted p-values for multiple testing are based on a Benjamini-Hochberg procedure on the test dataset